Requirements: 1. Maintain the original format and structure. 2. The translation should be accurate, fluent, and natural. 3. Maintain professionalism and consistency. 4. Only return the translation result; do not add any explanations. Original Text: As a dipeptide precursor of glutamine, Jingjing Pharmaceutical's alanylglutamine offers several key advantages that address the main issues associated with glutamine, such as stability, bioavailability, and safety, especially in the context of clinical critical care nutrition support. I. Core Advantages 1. **Stability**: Alanylglutamine from Jingjing Pharmaceutical does not require special storage, making it more convenient for clinical use. Glutamine solutions are highly unstable and prone to hydrolysis in high-temperature or acidic/alkaline environments, requiring refrigeration at 2-8°C. The peptide structure of alanylglutamine significantly enhances its stability, allowing it to be stored at room temperature for extended periods without the need for refrigeration. It can also be formulated in high concentrations (up to 20%) and mixed with other parenteral nutrition solutions (such as glucose and amino acids) without the risk of precipitation or decomposition. 2. **Bioavailability**: Alanylglutamine is delivered to the target site, resulting in nearly 100% absorption. After oral administration, about 30%-40% of glutamine is rapidly broken down by intestinal glutaminases; however, after intravenous infusion, more than 50% of alanylglutamine is quickly metabolized by the liver and kidneys, leading to low effective utilization. As a dipeptide, alanylglutamine can pass through the intestinal mucosal barrier and vascular endothelial cells, where it is specifically hydrolyzed by dipeptidases on the surface of target organs, releasing glutamine and alanine. This process results in nearly 100% bioavailability, ensuring no waste during transport. 3. **Metabolic Safety**: Alanylglutamine produces less ammonia during metabolism, improving tolerance. Glutamine metabolism generates significant amounts of ammonia, which can cause gastrointestinal reactions such as bloating, diarrhea, and nausea, and increase the burden on the liver and kidneys. Alanylglutamine produces only half the amount of ammonia compared to glutamine, significantly reducing the risk of hyperammonemia. The released alanine can be used for gluconeogenesis to provide energy and reduce lactic acid accumulation, making it suitable for use in patients with impaired liver and kidney function. 4. **Flexibility of Administration**: Alanylglutamine is well-suited for critical care patients with high dosage requirements. Traditional glutamine formulations have low concentrations and poor stability, making it difficult to meet the high needs of these patients. Oral formulations are not suitable for fasting patients or those with intestinal dysfunction. Alanylglutamine is primarily administered via intravenous infusion, with concentrations ranging from 10%-20%, allowing for dose adjustment as needed to meet the high demands of critically ill patients. It can also be directly added to parenteral nutrition (TPN) solutions, making it ideal for use in ICU settings and postoperative fasting scenarios. 5. **Clinical Efficacy**: Alanylglutamine provides enhanced support in critical care, with more significant repair effects. In states of severe stress (such as severe infections, extensive burns, or major surgeries), it rapidly increases glutamine levels in the body, effectively protects the intestinal barrier, enhances immune cell function, and reduces hospital stay and the incidence of infection complications. For conditions where the intestinal barrier is damaged (such as inflammatory bowel disease, short bowel syndrome, or severe diarrhea), the targeted delivery of alanylglutamine directly repairs intestinal mucosal cells, promotes intestinal epithelial regeneration, and improves intestinal absorption function, outperforming glutamine in these regards. II. Summary of Core Advantages | Dimension | Advantages of Alanylglutamine | |-----------------|------------------------------------------------------| | Stability | Can be stored at room temperature; stable in high concentrations; can be mixed with parenteral nutrition | | Bioavailability | Nearly 100% absorption; targeted delivery with no waste | | Metabolic Safety | Less ammonia production; reduced burden on the liver and kidneys; improved tolerance | | Flexibility of Administration | High-concentration intravenous formulations; suitable for critically ill/patient on fasting | | Clinical Efficacy | Enhanced support in critical care; improved intestinal repair and immune function | The essential advantages of Jingjing Pharmaceutical's alanylglutamine are its higher stability, efficiency, safety, and suitability for clinical needs, particularly in patients with critical illnesses, intestinal dysfunction, or high-dose supplementation requirements, making it a clear superior option compared to glutamine.