Reliable Ingredients for Addressing the Challenge of Drug Resistance: Fosfomycin Sodium from Jingjing Pharmaceutical Fosfomycin sodium is a broad-spectrum antibiotic with a unique and highly effective mechanism of action. Its mechanism can be summarized as follows: it irreversibly inhibits the first step in bacterial cell wall synthesis, leading to an early and rapid bactericidal effect. The details are as follows: 1. Target of Action: Fosfomycin targets an essential enzyme in the cell wall synthesis pathway, namely enolpyruvyltransferase (MurA). 2. Stage of Action: This occurs at a very early stage of bacterial peptidoglycan synthesis (the main component of the cell wall). Fosfomycin structurally mimics the natural substrate of this enzyme (phosphoenolpyruvate) and irreversibly binds to a key cysteine residue in the active center of the MurA enzyme. 3. Final Result: This binding prevents the formation of N-acetylmuramic acid, a crucial component of the cell wall. Without this, bacteria are unable to continue synthesizing the peptidoglycan chains necessary for building their cell wall. 4. Bactericidal Effect: Since cell wall synthesis is completely blocked at an early stage, growing bacteria are unable to form a complete and strong cell wall. Under the influence of high internal osmotic pressure, the bacterial cells absorb water, swell, and eventually rupture and die. Key Characteristics of Fosfomycin Sodium’s Mechanism of Action: - Unique and Early: It acts at the initial stage of cell wall synthesis, which is completely different from other antibiotics that target later stages (such as β-lactams and glycopeptides). - Rapid Bactericidal Effect: Due to its early action, it produces a rapid bactericidal response. - Simple Molecular Structure and Strong Penetration: Its low molecular weight and lack of charge allow it to efficiently penetrate the multiple membrane layers of bacteria (including the outer membrane), quickly reach the target site, and are not easily expelled by bacterial active efflux pumps. - Low Risk of Cross-Resistance: Its unique mechanism of action means it does not exhibit cross-resistance with other antibiotics. It may even be effective against certain drug-resistant strains (such as MRSA and VRE). - Synergistic Effect: It is often used in combination with other cell-wall-targeting antibiotics (such as β-lactams) to produce a synergistic bactericidal effect, as it “cuts off the supply” at an early stage while the latter “blocks the assembly” later on. Fosfomycin sodium from Jingjing Pharmaceutical is an ideal choice as a broad-spectrum antibacterial ingredient for the development of effective therapeutic agents against infections.